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The overall target of Dr. Gamble's study program is to investigate environmental modulation of circadian clock function in mammalian systems and the contribution of clock disruption to pathological disease. One of the most fascinating discoveries that has emerged in current years is that the circadian molecular clock regulates excitability in neurons that are spontaneously active in the absence of synaptic input. We are interested in how nutrition and disease influence clock-driven modifications in physiology and behavior in brain regions such as the SCN, hippocampus and substantia nigra.

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• There are numerous land-primarily based casinos operating there, but they only admit tourists and foreigners.
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